Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Calcium chloride
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Calcium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium can reverse the effects of calcium channel blockers, and it is used as an antidote in amlodipine overdose. Thiazide diuretics also reduce calcium excretion and may add to hypercalcemia.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Calcium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Raised extracellular calcium antagonizes L-type calcium channel blockade; thiazides decrease renal calcium loss.
What to do
Monitor blood pressure and serum calcium when parenteral calcium is given. Expect a reduced amlodipine effect and adjust therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Calcium chloride?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Calcium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium can reverse the effects of calcium channel blockers, and it is used as an antidote in amlodipine overdose. Thiazide diuretics also reduce calcium excretion and may add to hypercalcemia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Calcium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum calcium when parenteral calcium is given. Expect a reduced amlodipine effect and adjust therapy if needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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