Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Calcium citrate
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Calcium citrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium supplements may modestly reduce the antihypertensive effect of amlodipine. Hydrochlorothiazide lowers urinary calcium excretion, so high-dose calcium can contribute to hypercalcemia.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Calcium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Higher extracellular calcium partly opposes calcium channel blockade, and thiazides reduce renal calcium excretion.
What to do
Monitor blood pressure and serum calcium during long-term high-dose supplementation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Calcium citrate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Calcium citrate?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Calcium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium supplements may modestly reduce the antihypertensive effect of amlodipine. Hydrochlorothiazide lowers urinary calcium excretion, so high-dose calcium can contribute to hypercalcemia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Calcium citrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum calcium during long-term high-dose supplementation.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
