Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Carbenoxolone
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Carbenoxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss. With hydrochlorothiazide, hypokalemia is more likely and sodium and fluid retention may reduce blood pressure control. Valsartan only partly offsets potassium loss.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Carbenoxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting from thiazide and carbenoxolone's mineralocorticoid effect, which also opposes antihypertensive therapy.
What to do
Monitor serum potassium and blood pressure, and replace potassium as needed. Avoid the combination in patients with heart disease or on digoxin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Carbenoxolone?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Carbenoxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss. With hydrochlorothiazide, hypokalemia is more likely and sodium and fluid retention may reduce blood pressure control. Valsartan only partly offsets potassium loss.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Carbenoxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and replace potassium as needed. Avoid the combination in patients with heart disease or on digoxin.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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