Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Carvedilol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol adds beta-blockade and alpha-1 blockade to a regimen that already contains a calcium channel blocker, a thiazide and an ARB. The combination can cause excessive blood pressure reduction, dizziness, and bradycardia, and beta-blockers can mask hypoglycemia and slightly raise potassium. Combined antihypertensive therapy is often used deliberately and is generally manageable.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Carvedilol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering through vasodilation, beta-adrenergic blockade, diuresis and renin-angiotensin blockade.
What to do
Monitor blood pressure, heart rate and orthostatic symptoms when carvedilol is started or the dose is raised, and adjust doses accordingly. Check potassium and renal function periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Carvedilol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol adds beta-blockade and alpha-1 blockade to a regimen that already contains a calcium channel blocker, a thiazide and an ARB. The combination can cause excessive blood pressure reduction, dizziness, and bradycardia, and beta-blockers can mask hypoglycemia and slightly raise potassium. Combined antihypertensive therapy is often used deliberately and is generally manageable.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and orthostatic symptoms when carvedilol is started or the dose is raised, and adjust doses accordingly. Check potassium and renal function periodically.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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