Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Celiprolol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Celiprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celiprolol adds to the blood pressure lowering of amlodipine, hydrochlorothiazide and valsartan, which may cause hypotension. Hydrochlorothiazide can also reduce celiprolol absorption, lowering its effect.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Celiprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive pharmacodynamic effects, plus reduced oral absorption of celiprolol with thiazides.
What to do
Monitor blood pressure and heart rate and adjust doses as needed. Check for loss of celiprolol effect if absorption is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Celiprolol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Celiprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celiprolol adds to the blood pressure lowering of amlodipine, hydrochlorothiazide and valsartan, which may cause hypotension. Hydrochlorothiazide can also reduce celiprolol absorption, lowering its effect.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Celiprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust doses as needed. Check for loss of celiprolol effect if absorption is reduced.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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