Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Cenobamate
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and can lower amlodipine concentrations. This may reduce blood pressure control.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Cenobamate belongs to Central Nervous System.
Why it happens
Cenobamate induces CYP3A4, increasing the metabolic clearance of amlodipine.
What to do
Monitor blood pressure when cenobamate is started or adjusted. Increase the amlodipine dose if needed and reassess if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Cenobamate?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and can lower amlodipine concentrations. This may reduce blood pressure control.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when cenobamate is started or adjusted. Increase the amlodipine dose if needed and reassess if cenobamate is stopped.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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