Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Choline magnesium trisalicylate
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Choline magnesium trisalicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at anti-inflammatory doses can blunt the effect of valsartan and hydrochlorothiazide, and with the diuretic may cause acute kidney injury, particularly in elderly or volume-depleted patients. Hyperkalemia is also possible.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces renal perfusion, sodium excretion and antihypertensive response.
What to do
Ensure hydration and monitor blood pressure, serum creatinine and potassium. Use the lowest effective salicylate dose or switch to an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Choline magnesium trisalicylate?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at anti-inflammatory doses can blunt the effect of valsartan and hydrochlorothiazide, and with the diuretic may cause acute kidney injury, particularly in elderly or volume-depleted patients. Hyperkalemia is also possible.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Choline magnesium trisalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure hydration and monitor blood pressure, serum creatinine and potassium. Use the lowest effective salicylate dose or switch to an alternative analgesic.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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