Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Cortisone
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Cortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone has mineralocorticoid activity that promotes potassium loss, which adds to the potassium-wasting effect of hydrochlorothiazide. This raises the risk of hypokalemia and, in some patients, fluid retention that opposes the antihypertensive effect.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting and sodium retention from corticosteroid and thiazide actions.
What to do
Monitor serum potassium and blood pressure, and replace potassium as needed. Valsartan may partly offset potassium loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Cortisone?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone has mineralocorticoid activity that promotes potassium loss, which adds to the potassium-wasting effect of hydrochlorothiazide. This raises the risk of hypokalemia and, in some patients, fluid retention that opposes the antihypertensive effect.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Cortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and replace potassium as needed. Valsartan may partly offset potassium loss.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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