Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Cyclopenthiazide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Cyclopenthiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is duplicate thiazide therapy and increases risk of hypokalemia, hyponatremia, hypotension and metabolic effects without clear added benefit.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Cyclopenthiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of the distal tubular sodium-chloride cotransporter.
What to do
Avoid combining two thiazides. If unavoidable, monitor serum electrolytes and renal function closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Cyclopenthiazide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Cyclopenthiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This is duplicate thiazide therapy and increases risk of hypokalemia, hyponatremia, hypotension and metabolic effects without clear added benefit.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Cyclopenthiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazides. If unavoidable, monitor serum electrolytes and renal function closely.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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