Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Cyclosporine
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine with hydrochlorothiazide can increase uric acid and may worsen hyperkalemia and renal function with valsartan. Amlodipine can modestly raise cyclosporine levels, and cyclosporine can raise amlodipine levels.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxic, hyperuricemic and potassium-retaining effects, plus CYP3A4/P-gp interplay with amlodipine.
What to do
Monitor creatinine, potassium, sodium, uric acid and cyclosporine trough levels. Adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Cyclosporine?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine with hydrochlorothiazide can increase uric acid and may worsen hyperkalemia and renal function with valsartan. Amlodipine can modestly raise cyclosporine levels, and cyclosporine can raise amlodipine levels.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine, potassium, sodium, uric acid and cyclosporine trough levels. Adjust doses as needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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