Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Dabrafenib
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and can reduce amlodipine exposure, with a possible loss of antihypertensive effect. The effect develops over days to weeks as induction builds.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, accelerating amlodipine metabolism.
What to do
Monitor blood pressure during dabrafenib therapy. Titrate the amlodipine dose upward or add another agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Dabrafenib?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and can reduce amlodipine exposure, with a possible loss of antihypertensive effect. The effect develops over days to weeks as induction builds.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during dabrafenib therapy. Titrate the amlodipine dose upward or add another agent if needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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