Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Danazol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Danazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and may modestly increase amlodipine levels. Danazol can also cause fluid retention and raise blood pressure, working against the antihypertensive therapy.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition reduces amlodipine clearance; danazol's androgenic effects cause fluid retention.
What to do
Monitor blood pressure and edema and adjust amlodipine accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Danazol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and may modestly increase amlodipine levels. Danazol can also cause fluid retention and raise blood pressure, working against the antihypertensive therapy.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Danazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema and adjust amlodipine accordingly.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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