Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Deferasirox
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Deferasirox: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 modestly in some patients, which could lower amlodipine concentrations and weaken blood pressure control. The effect is variable and generally small. Deferasirox can also affect kidney function, which matters with an ARB and a diuretic.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Deferasirox have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Deferasirox belongs to Miscellaneous.
Why it happens
Possible CYP3A4 induction by deferasirox increases amlodipine metabolism.
What to do
Monitor blood pressure after deferasirox is started and adjust amlodipine if control worsens. Monitor renal function because of the ARB and diuretic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Deferasirox?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Deferasirox have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferasirox can induce CYP3A4 modestly in some patients, which could lower amlodipine concentrations and weaken blood pressure control. The effect is variable and generally small. Deferasirox can also affect kidney function, which matters with an ARB and a diuretic.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Deferasirox?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after deferasirox is started and adjust amlodipine if control worsens. Monitor renal function because of the ARB and diuretic.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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