Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Dichlorphenamide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide is a carbonic anhydrase inhibitor that causes renal potassium loss and metabolic acidosis. Combined with hydrochlorothiazide, it increases the risk of hypokalemia and electrolyte disturbance. The legacy statement about amlodipine lowering potassium is not accurate.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive renal potassium and bicarbonate wasting from carbonic anhydrase inhibition and thiazide action.
What to do
Monitor serum potassium and bicarbonate regularly, particularly at initiation and after dose changes, and supplement potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Dichlorphenamide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide is a carbonic anhydrase inhibitor that causes renal potassium loss and metabolic acidosis. Combined with hydrochlorothiazide, it increases the risk of hypokalemia and electrolyte disturbance. The legacy statement about amlodipine lowering potassium is not accurate.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly, particularly at initiation and after dose changes, and supplement potassium as needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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