Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Diltiazem
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem inhibits CYP3A4 and increases amlodipine exposure, which can cause excessive vasodilation, hypotension and edema. Diltiazem also has its own blood pressure and heart-rate lowering effects, adding to the antihypertensive burden.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Diltiazem belongs to Cardiovascular.
Why it happens
Diltiazem inhibits CYP3A4 metabolism of amlodipine, plus additive calcium channel blockade.
What to do
Avoid duplicate calcium channel blocker therapy where possible. If combined, monitor blood pressure, heart rate and edema and lower the amlodipine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Diltiazem?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem inhibits CYP3A4 and increases amlodipine exposure, which can cause excessive vasodilation, hypotension and edema. Diltiazem also has its own blood pressure and heart-rate lowering effects, adding to the antihypertensive burden.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate calcium channel blocker therapy where possible. If combined, monitor blood pressure, heart rate and edema and lower the amlodipine dose as needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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