Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Encorafenib
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib inhibits OATP1B1/1B3 and may raise valsartan exposure. It also has mixed effects on CYP3A4 that make amlodipine concentrations unpredictable.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Encorafenib belongs to Oncology.
Why it happens
OATP1B1/1B3 inhibition may increase valsartan levels; encorafenib both inhibits and induces CYP3A4.
What to do
Monitor blood pressure and adjust valsartan or amlodipine doses if hypotension or loss of control occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Encorafenib?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib inhibits OATP1B1/1B3 and may raise valsartan exposure. It also has mixed effects on CYP3A4 that make amlodipine concentrations unpredictable.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust valsartan or amlodipine doses if hypotension or loss of control occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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