Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Erythromycin base
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Erythromycin base: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and can increase amlodipine concentrations, raising the risk of hypotension and edema.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Erythromycin base can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism.
What to do
Monitor blood pressure during and after the antibiotic course, and consider a lower amlodipine dose in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Erythromycin base?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Erythromycin base can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and can increase amlodipine concentrations, raising the risk of hypotension and edema.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Erythromycin base?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during and after the antibiotic course, and consider a lower amlodipine dose in elderly patients.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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