Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Fenbufen
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen can reduce the antihypertensive effect of valsartan and hydrochlorothiazide and impair renal function, particularly in older or volume-depleted patients. Hyperkalemia and acute kidney injury may occur with an ARB. The thiazide component adds to the volume-depletion risk.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, reducing renal perfusion, promoting sodium retention and impairing potassium excretion alongside angiotensin receptor blockade.
What to do
Monitor blood pressure, serum creatinine and potassium, and keep the patient hydrated. Use the lowest NSAID dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Fenbufen?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen can reduce the antihypertensive effect of valsartan and hydrochlorothiazide and impair renal function, particularly in older or volume-depleted patients. Hyperkalemia and acute kidney injury may occur with an ARB. The thiazide component adds to the volume-depletion risk.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and keep the patient hydrated. Use the lowest NSAID dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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