Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Fenoprofen
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen can reduce the antihypertensive effect of valsartan and hydrochlorothiazide and, together with an ARB and a diuretic, raises the risk of acute kidney injury and hyperkalemia. The risk is highest in older, dehydrated or renally impaired patients.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium retention and reduced renal perfusion, opposing diuretic and ARB effects.
What to do
Limit NSAID dose and duration, ensure adequate hydration, and monitor blood pressure, serum creatinine and potassium. Choose a non-NSAID analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Fenoprofen?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen can reduce the antihypertensive effect of valsartan and hydrochlorothiazide and, together with an ARB and a diuretic, raises the risk of acute kidney injury and hyperkalemia. The risk is highest in older, dehydrated or renally impaired patients.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit NSAID dose and duration, ensure adequate hydration, and monitor blood pressure, serum creatinine and potassium. Choose a non-NSAID analgesic where possible.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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