Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Fentanyl transdermal
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Fentanyl transdermal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl can add to hypotension and may blunt the diuretic effect of hydrochlorothiazide by promoting antidiuretic hormone release. The effect is generally modest.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Fentanyl transdermal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced antidiuretic hormone release and additive hypotensive effects.
What to do
Monitor blood pressure, fluid balance and edema. Adjust the diuretic if its effect is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Fentanyl transdermal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Fentanyl transdermal?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Fentanyl transdermal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fentanyl can add to hypotension and may blunt the diuretic effect of hydrochlorothiazide by promoting antidiuretic hormone release. The effect is generally modest.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Fentanyl transdermal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid balance and edema. Adjust the diuretic if its effect is lost.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
