Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Fentanyl transmucosal
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Fentanyl transmucosal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl can add to hypotension and may blunt the diuretic effect of hydrochlorothiazide by promoting antidiuretic hormone release. The effect is generally modest.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Fentanyl transmucosal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced antidiuretic hormone release and additive hypotensive effects.
What to do
Monitor blood pressure, fluid balance and edema. Adjust the diuretic if its effect is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Fentanyl transmucosal?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Fentanyl transmucosal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fentanyl can add to hypotension and may blunt the diuretic effect of hydrochlorothiazide by promoting antidiuretic hormone release. The effect is generally modest.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Fentanyl transmucosal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid balance and edema. Adjust the diuretic if its effect is lost.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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