Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Fentanyl
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl can cause hypotension, and combined with the antihypertensive triple combination the blood pressure drop may be greater, especially around anesthesia or on dose initiation. Opioids may also promote urinary retention and antidiuretic hormone release, which can blunt diuretic effect.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Fentanyl belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects (vasodilation and reduced sympathetic tone) plus opioid-related ADH release and urinary retention opposing diuresis.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing fentanyl, and watch for urinary retention or reduced diuretic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Fentanyl?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fentanyl can cause hypotension, and combined with the antihypertensive triple combination the blood pressure drop may be greater, especially around anesthesia or on dose initiation. Opioids may also promote urinary retention and antidiuretic hormone release, which can blunt diuretic effect.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing fentanyl, and watch for urinary retention or reduced diuretic response.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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