Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Fexinidazole
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and raise amlodipine levels, with possible hypotension and edema. Fexinidazole also prolongs QT, but this is not changed by the antihypertensives.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition reducing amlodipine metabolism.
What to do
Monitor blood pressure and edema during the short fexinidazole course. Reduce the amlodipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Fexinidazole?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and raise amlodipine levels, with possible hypotension and edema. Fexinidazole also prolongs QT, but this is not changed by the antihypertensives.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during the short fexinidazole course. Reduce the amlodipine dose if needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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