Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Fosamprenavir
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amprenavir, the active form of fosamprenavir, inhibits CYP3A4 and can raise amlodipine levels. This may cause hypotension, edema and dizziness.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amprenavir inhibits CYP3A4-mediated amlodipine metabolism.
What to do
Monitor blood pressure and for edema during co-administration. Consider a lower amlodipine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Fosamprenavir?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amprenavir, the active form of fosamprenavir, inhibits CYP3A4 and can raise amlodipine levels. This may cause hypotension, edema and dizziness.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema during co-administration. Consider a lower amlodipine dose if adverse effects appear.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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