Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Glibenclamide
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Glibenclamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide may inhibit OATP1B1 and could modestly increase valsartan exposure, but this is unlikely to be clinically important. Thiazides can also reduce glycemic control, which may be relevant in a diabetic taking glyburide.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Glibenclamide belongs to Endocrine.
Why it happens
Possible OATP1B1 inhibition by glyburide reducing hepatic uptake of valsartan.
What to do
No empiric adjustment is needed for valsartan. Monitor blood pressure and blood glucose, as hydrochlorothiazide can raise glucose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Glibenclamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Glibenclamide?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glyburide may inhibit OATP1B1 and could modestly increase valsartan exposure, but this is unlikely to be clinically important. Thiazides can also reduce glycemic control, which may be relevant in a diabetic taking glyburide.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Glibenclamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric adjustment is needed for valsartan. Monitor blood pressure and blood glucose, as hydrochlorothiazide can raise glucose.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
