Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Indinavir
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a strong CYP3A4 inhibitor, so it can raise amlodipine levels, causing hypotension and edema. It may also raise valsartan exposure via OATP1B1 inhibition, though the clinical importance is uncertain.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4 metabolism of amlodipine and may inhibit OATP1B1 uptake of valsartan.
What to do
Monitor blood pressure and for edema during co-administration. Reduce the amlodipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Indinavir?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a strong CYP3A4 inhibitor, so it can raise amlodipine levels, causing hypotension and edema. It may also raise valsartan exposure via OATP1B1 inhibition, though the clinical importance is uncertain.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema during co-administration. Reduce the amlodipine dose if hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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