Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Insulin aspart protamine / insulin aspart
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Insulin aspart protamine / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan may improve insulin sensitivity and enhance the glucose-lowering effect of insulin, occasionally causing hypoglycemia. Hydrochlorothiazide in the combination product can have the opposite effect and raise glucose. Net effects on glycemic control are variable.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARBs may improve insulin sensitivity while thiazides impair glucose tolerance, giving variable effects on glycemia.
What to do
Monitor blood glucose more closely when starting or changing the antihypertensive. Adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Insulin aspart protamine / insulin aspart?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan may improve insulin sensitivity and enhance the glucose-lowering effect of insulin, occasionally causing hypoglycemia. Hydrochlorothiazide in the combination product can have the opposite effect and raise glucose. Net effects on glycemic control are variable.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Insulin aspart protamine / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely when starting or changing the antihypertensive. Adjust the insulin dose as needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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