Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Insulin aspart
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity and can enhance the glucose-lowering effect of insulin, occasionally leading to hypoglycemia. Hydrochlorothiazide can have the opposite effect and raise blood glucose, so glycemic control may shift in either direction.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Insulin aspart belongs to Endocrine.
Why it happens
ARB-related improvement in insulin sensitivity increases insulin effect, while thiazide-induced glucose intolerance may counteract it.
What to do
Monitor blood glucose more frequently when the combination is started, changed or stopped, and adjust the insulin aspart dose accordingly. Counsel the patient on recognising hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Insulin aspart
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Insulin aspart?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may improve insulin sensitivity and can enhance the glucose-lowering effect of insulin, occasionally leading to hypoglycemia. Hydrochlorothiazide can have the opposite effect and raise blood glucose, so glycemic control may shift in either direction.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when the combination is started, changed or stopped, and adjust the insulin aspart dose accordingly. Counsel the patient on recognising hypoglycemia.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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