Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Insulin degludec / insulin aspart
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan may enhance insulin sensitivity and increase hypoglycemia risk, while hydrochlorothiazide can raise blood glucose and reduce insulin effectiveness. Glycemic control may therefore change when this combination is started or altered.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARBs may improve insulin sensitivity while thiazides impair glucose tolerance, partly via hypokalemia.
What to do
Monitor blood glucose and potassium after starting or changing therapy. Adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan may enhance insulin sensitivity and increase hypoglycemia risk, while hydrochlorothiazide can raise blood glucose and reduce insulin effectiveness. Glycemic control may therefore change when this combination is started or altered.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium after starting or changing therapy. Adjust the insulin dose as needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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