Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Levalbuterol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Levalbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levalbuterol can lower serum potassium, and hydrochlorothiazide does the same. Together they may cause clinically relevant hypokalemia with a risk of arrhythmia, especially with high or frequent beta-agonist doses.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonism shifts potassium into cells while thiazides increase renal potassium loss, giving additive hypokalemia.
What to do
Check serum potassium in patients using frequent or high-dose levalbuterol and replace potassium as needed. Valsartan partly offsets the loss but does not remove the need for monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Levalbuterol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levalbuterol can lower serum potassium, and hydrochlorothiazide does the same. Together they may cause clinically relevant hypokalemia with a risk of arrhythmia, especially with high or frequent beta-agonist doses.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Levalbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in patients using frequent or high-dose levalbuterol and replace potassium as needed. Valsartan partly offsets the loss but does not remove the need for monitoring.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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