Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Magnesium supplement
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Magnesium supplement: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium has vasodilating and calcium-antagonizing effects and may add to the hypotensive action of amlodipine. With parenteral magnesium, excessive hypotension or neuromuscular effects are possible. Oral supplements are less likely to cause problems.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Magnesium supplement have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Magnesium acts as a physiological calcium antagonist, producing additive vasodilation with calcium channel blockers.
What to do
Monitor blood pressure, particularly with intravenous magnesium. Oral supplementation generally needs no change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Magnesium supplement?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Magnesium supplement have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Magnesium has vasodilating and calcium-antagonizing effects and may add to the hypotensive action of amlodipine. With parenteral magnesium, excessive hypotension or neuromuscular effects are possible. Oral supplements are less likely to cause problems.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Magnesium supplement?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, particularly with intravenous magnesium. Oral supplementation generally needs no change.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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