Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Meclofenamate
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Meclofenamate: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can blunt the antihypertensive effect of valsartan and hydrochlorothiazide. In volume-depleted or older patients, the combination of an NSAID, an ARB and a diuretic increases the risk of acute kidney injury and hyperkalemia.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, causing sodium and water retention and reduced renal perfusion, which opposes diuretic and ARB effects and impairs glomerular filtration.
What to do
Avoid or limit NSAID use where possible, ensuring adequate hydration. Monitor blood pressure, serum creatinine and potassium, particularly early in therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Meclofenamate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Meclofenamate?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as meclofenamate can blunt the antihypertensive effect of valsartan and hydrochlorothiazide. In volume-depleted or older patients, the combination of an NSAID, an ARB and a diuretic increases the risk of acute kidney injury and hyperkalemia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Meclofenamate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit NSAID use where possible, ensuring adequate hydration. Monitor blood pressure, serum creatinine and potassium, particularly early in therapy.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
