Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Metaproterenol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol can lower serum potassium, and hydrochlorothiazide adds to this. The resulting hypokalemia may provoke arrhythmias, especially at high beta-agonist doses.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 stimulation drives potassium into cells while thiazides promote renal potassium loss.
What to do
Monitor serum potassium in patients using frequent or high-dose metaproterenol and replace as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Metaproterenol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaproterenol can lower serum potassium, and hydrochlorothiazide adds to this. The resulting hypokalemia may provoke arrhythmias, especially at high beta-agonist doses.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients using frequent or high-dose metaproterenol and replace as needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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