Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Methotrexate
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides may reduce renal elimination of methotrexate and have been reported to increase its myelosuppression. Risk is greater with higher methotrexate doses or renal impairment, and volume depletion with valsartan can worsen it.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Methotrexate belongs to Oncology.
Why it happens
Reduced renal clearance of methotrexate from diuretic-related volume depletion and tubular competition.
What to do
Monitor complete blood counts and renal function, and consider methotrexate dose reduction; use extra caution with high-dose methotrexate regimens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Methotrexate?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides may reduce renal elimination of methotrexate and have been reported to increase its myelosuppression. Risk is greater with higher methotrexate doses or renal impairment, and volume depletion with valsartan can worsen it.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function, and consider methotrexate dose reduction; use extra caution with high-dose methotrexate regimens.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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