Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Methyclothiazide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a duplication of thiazide therapy, since the combination product already contains hydrochlorothiazide. It increases the risk of volume depletion, hypotension, hyponatremia, hypokalemia and renal impairment, partly offset by valsartan's potassium-sparing effect.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Two thiazide diuretics produce additive natriuresis and potassium wasting.
What to do
Avoid combining two thiazides and stop the redundant agent. If unavoidable, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Methyclothiazide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This is a duplication of thiazide therapy, since the combination product already contains hydrochlorothiazide. It increases the risk of volume depletion, hypotension, hyponatremia, hypokalemia and renal impairment, partly offset by valsartan's potassium-sparing effect.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazides and stop the redundant agent. If unavoidable, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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