Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Midazolam intranasal
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Midazolam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may slightly increase midazolam exposure. This could prolong sedation, and additive hypotension is also possible.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by amlodipine reduces midazolam clearance.
What to do
Observe for prolonged sedation and hypotension after intranasal midazolam. No empirical dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Midazolam intranasal?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amlodipine is a weak CYP3A4 inhibitor and may slightly increase midazolam exposure. This could prolong sedation, and additive hypotension is also possible.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Midazolam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe for prolonged sedation and hypotension after intranasal midazolam. No empirical dose change is usually needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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