Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Moxisylyte
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Moxisylyte: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxisylyte is an alpha-blocking vasodilator and may add to the hypotensive effect of amlodipine and the other antihypertensive components. Dizziness or postural hypotension can occur.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Moxisylyte can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-adrenergic blockade combined with calcium channel blockade, diuresis and angiotensin receptor blockade produces additive vasodilation.
What to do
Monitor blood pressure, especially standing pressure, when starting moxisylyte. Reduce doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Moxisylyte?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Moxisylyte can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxisylyte is an alpha-blocking vasodilator and may add to the hypotensive effect of amlodipine and the other antihypertensive components. Dizziness or postural hypotension can occur.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Moxisylyte?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially standing pressure, when starting moxisylyte. Reduce doses if symptomatic hypotension develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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