Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Nefazodone
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a potent CYP3A4 inhibitor and can raise amlodipine concentrations. This may cause hypotension, dizziness and peripheral edema.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone inhibits CYP3A4, reducing amlodipine metabolism.
What to do
Monitor blood pressure and edema, and consider a lower amlodipine dose. Reassess if nefazodone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Nefazodone?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a potent CYP3A4 inhibitor and can raise amlodipine concentrations. This may cause hypotension, dizziness and peripheral edema.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and consider a lower amlodipine dose. Reassess if nefazodone is stopped.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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