Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Nitroglycerin sublingual
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Nitroglycerin sublingual: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin and the antihypertensive components all lower blood pressure, so combined use can cause marked orthostatic hypotension, syncope or reflex tachycardia. Sublingual doses taken for angina are the usual trigger.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Nitroglycerin sublingual can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and blood pressure lowering.
What to do
Advise patients to sit when taking nitroglycerin and rise slowly. Monitor blood pressure and adjust antihypertensives if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Nitroglycerin sublingual?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Nitroglycerin sublingual can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin and the antihypertensive components all lower blood pressure, so combined use can cause marked orthostatic hypotension, syncope or reflex tachycardia. Sublingual doses taken for angina are the usual trigger.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Nitroglycerin sublingual?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to sit when taking nitroglycerin and rise slowly. Monitor blood pressure and adjust antihypertensives if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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