Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Olmesartan
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Olmesartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan duplicates the angiotensin receptor blockade of valsartan. Dual ARB therapy adds no proven benefit and increases the risk of hypotension, hyperkalemia, and renal impairment.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Olmesartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II type 1 receptor blockade, producing additive hypotension, reduced glomerular filtration and potassium retention.
What to do
Avoid combining two ARBs; use only one. If both have been taken, monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Olmesartan?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olmesartan duplicates the angiotensin receptor blockade of valsartan. Dual ARB therapy adds no proven benefit and increases the risk of hypotension, hyperkalemia, and renal impairment.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Olmesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ARBs; use only one. If both have been taken, monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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