Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Olodaterol inhaled
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydrochlorothiazide and beta-2 agonists can lower serum potassium. Together they may produce clinically relevant hypokalemia, which can promote arrhythmias, particularly in patients with cardiac disease or hypoxia. Systemic exposure to inhaled olodaterol is low, so the effect is usually modest.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium lowering: thiazide-induced renal potassium loss plus beta-2 agonist-driven intracellular potassium shift.
What to do
Check serum potassium at baseline and periodically, especially in patients with severe COPD or cardiac disease. Replace potassium if levels are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both hydrochlorothiazide and beta-2 agonists can lower serum potassium. Together they may produce clinically relevant hypokalemia, which can promote arrhythmias, particularly in patients with cardiac disease or hypoxia. Systemic exposure to inhaled olodaterol is low, so the effect is usually modest.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium at baseline and periodically, especially in patients with severe COPD or cardiac disease. Replace potassium if levels are low.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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