Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted paritaprevir inhibits CYP3A4 and raises amlodipine exposure, increasing the risk of hypotension and peripheral edema. Valsartan exposure may also increase through inhibition of hepatic transporters.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by ritonavir reduces amlodipine clearance, and transporter inhibition (OATP/MRP2) may raise valsartan levels.
What to do
Reduce the amlodipine dose by about half, or use a different antihypertensive, and monitor for hypotension and edema. Monitor blood pressure and renal function for valsartan-related effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted paritaprevir inhibits CYP3A4 and raises amlodipine exposure, increasing the risk of hypotension and peripheral edema. Valsartan exposure may also increase through inhibition of hepatic transporters.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the amlodipine dose by about half, or use a different antihypertensive, and monitor for hypotension and edema. Monitor blood pressure and renal function for valsartan-related effects.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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