Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Paclitaxel protein bound
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Paclitaxel protein bound: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is a substrate of hepatic uptake transporters, and OATP1B1 inhibition could increase its exposure. Paclitaxel is not an established clinically significant inhibitor of this transporter, so any effect is theoretical.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan; not established clinically.
What to do
No specific action is needed beyond routine monitoring of blood pressure during chemotherapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Paclitaxel protein bound?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is a substrate of hepatic uptake transporters, and OATP1B1 inhibition could increase its exposure. Paclitaxel is not an established clinically significant inhibitor of this transporter, so any effect is theoretical.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Paclitaxel protein bound?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of blood pressure during chemotherapy.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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