Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Parecoxib
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib, through its active metabolite valdecoxib, can blunt the antihypertensive effect of thiazides and ARBs. In volume-depleted or elderly patients, the combination raises the risk of acute kidney injury and hyperkalemia.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and reduces renal perfusion, which opposes diuretic and ARB effects.
What to do
Monitor blood pressure, renal function and serum potassium, especially at the start of therapy. Ensure adequate hydration and use the lowest effective parecoxib dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Parecoxib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Parecoxib?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib, through its active metabolite valdecoxib, can blunt the antihypertensive effect of thiazides and ARBs. In volume-depleted or elderly patients, the combination raises the risk of acute kidney injury and hyperkalemia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and serum potassium, especially at the start of therapy. Ensure adequate hydration and use the lowest effective parecoxib dose for the shortest time.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
