Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Phenoxybenzamine
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Phenoxybenzamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine is a long-acting alpha-blocker, and combining it with other antihypertensives produces additive hypotension, including orthostatic hypotension. Reflex tachycardia and dizziness may occur.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure lowering through alpha-adrenergic blockade plus calcium channel blockade, RAAS inhibition and diuresis.
What to do
Monitor blood pressure, including standing readings, and titrate doses slowly. Reduce the dose of the antihypertensives if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine is a long-acting alpha-blocker, and combining it with other antihypertensives produces additive hypotension, including orthostatic hypotension. Reflex tachycardia and dizziness may occur.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, and titrate doses slowly. Reduce the dose of the antihypertensives if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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