Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Procainamide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Procainamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may reduce renal tubular secretion of procainamide and its metabolite NAPA, raising their levels. Thiazide-induced hypokalemia may also increase the risk of proarrhythmia.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Procainamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular cationic secretion, plus thiazide-induced electrolyte disturbance.
What to do
Monitor ECG, serum procainamide and NAPA levels and serum potassium. Reduce the procainamide dose if levels or QRS or QT intervals increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Procainamide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Procainamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide may reduce renal tubular secretion of procainamide and its metabolite NAPA, raising their levels. Thiazide-induced hypokalemia may also increase the risk of proarrhythmia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Procainamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, serum procainamide and NAPA levels and serum potassium. Reduce the procainamide dose if levels or QRS or QT intervals increase.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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