Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Rapacuronium
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Rapacuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can enhance the effect of nondepolarizing neuromuscular blockers, prolonging paralysis. Rapacuronium is no longer marketed in most countries, so the issue is mainly of historical relevance.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcium channel blockade reduces presynaptic acetylcholine release, adding to neuromuscular blockade.
What to do
Monitor neuromuscular function with a nerve stimulator and titrate the blocker to effect. Ensure ventilatory support is available during recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Rapacuronium?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium channel blockers can enhance the effect of nondepolarizing neuromuscular blockers, prolonging paralysis. Rapacuronium is no longer marketed in most countries, so the issue is mainly of historical relevance.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Rapacuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and titrate the blocker to effect. Ensure ventilatory support is available during recovery.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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