Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Rifampin
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong CYP3A4 inducer and can substantially lower amlodipine levels, reducing antihypertensive effect. Rifampin may also inhibit hepatic uptake of valsartan after single doses, but the net clinical effect is unclear.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction increases amlodipine clearance, and OATP1B1 inhibition may alter valsartan hepatic uptake.
What to do
Monitor blood pressure closely during and after rifampin therapy. Increase the amlodipine dose or use an alternative if blood pressure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Rifampin?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a strong CYP3A4 inducer and can substantially lower amlodipine levels, reducing antihypertensive effect. Rifampin may also inhibit hepatic uptake of valsartan after single doses, but the net clinical effect is unclear.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during and after rifampin therapy. Increase the amlodipine dose or use an alternative if blood pressure rises.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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