Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Sacubitril / valsartan
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Sacubitril / valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This combination duplicates valsartan, since the product already contains it and sacubitril/valsartan adds a second ARB dose. This increases the risk of hypotension, hyperkalemia, renal impairment and angioedema. Dual ARB exposure offers no added benefit.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate angiotensin II receptor blockade with additive hypotensive and potassium-retaining effects.
What to do
Avoid concurrent use and replace the fixed-dose combination with agents lacking an ARB (such as amlodipine with hydrochlorothiazide) if sacubitril/valsartan is needed. If overlap is unavoidable, monitor blood pressure, potassium and creatinine closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Sacubitril / valsartan?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This combination duplicates valsartan, since the product already contains it and sacubitril/valsartan adds a second ARB dose. This increases the risk of hypotension, hyperkalemia, renal impairment and angioedema. Dual ARB exposure offers no added benefit.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Sacubitril / valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and replace the fixed-dose combination with agents lacking an ARB (such as amlodipine with hydrochlorothiazide) if sacubitril/valsartan is needed. If overlap is unavoidable, monitor blood pressure, potassium and creatinine closely.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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