Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Salicylates
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates can reduce renal prostaglandin synthesis, which may blunt the antihypertensive effect of valsartan and hydrochlorothiazide and impair renal function in volume-depleted or elderly patients. Potassium effects are unpredictable because the ARB tends to raise potassium while the thiazide lowers it.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins by salicylates opposes ARB and diuretic effects and reduces renal perfusion.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or changing salicylate therapy, and ensure adequate hydration. Consider a non-NSAID analgesic if blood pressure control or renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Salicylates?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates can reduce renal prostaglandin synthesis, which may blunt the antihypertensive effect of valsartan and hydrochlorothiazide and impair renal function in volume-depleted or elderly patients. Potassium effects are unpredictable because the ARB tends to raise potassium while the thiazide lowers it.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or changing salicylate therapy, and ensure adequate hydration. Consider a non-NSAID analgesic if blood pressure control or renal function worsens.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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